Part of Clavicular's Looksmaxxing Stack

TB-500 complements BPC-157 in the looksmaxxing recovery stack. Often recommended alongside Clavicular's core protocol for enhanced healing.

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Research Specifications

Active Sequence:: Ac-LKKTETQ (core actin-binding motif)
Full Name:: Thymosin Beta-4 fragment (synthetic analogue)
Molecular Weight:: 2174.5 Da
Form:: Lyophilized powder
Purity:: ≥98% (HPLC verified)
Storage:: −20°C long-term / 4°C up to 4 weeks reconstituted
Reconstitution:: Bacteriostatic water

TB-500 (Thymosin Beta-4) 10mg

Name: TB-500 (Thymosin Beta-4) 10mg
Brand: Phiogen
SKU: PG-1008
Price: 59.99 USD
Availability: InStock
Rating: 4.9 (47 reviews)

Featured in Clavicular's looksmaxxing protocol

Synthetic Thymosin Beta-4 fragment — researched for actin regulation, satellite cell activation, and systemic tissue repair. Part of Clavicular's recovery stack alongside BPC-157.

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Why Clavicular Uses This Peptide

TB-500 complements BPC-157 in the looksmaxxing recovery stack. Often recommended alongside Clavicular's core protocol for enhanced healing.

See Clavicular's complete looksmaxxing stack →

Actin Sequestration & Satellite Cell Activation

TB-500 is a synthetic analogue of the active Ac-LKKTETQ region of Thymosin Beta-4 (Tβ4), a 43-amino-acid peptide present in virtually all nucleated cells. Its primary mechanism is G-actin sequestration via the Ac-LKKTETQ motif — this promotes cell migration, angiogenesis, and tissue repair by controlling actin polymerization dynamics. TB-500 activates satellite cells (muscle stem cells), upregulates metalloproteinases for ECM remodeling, and reduces pro-inflammatory cytokines including TNF-α and IL-1β. Its systemic cell migration properties make it complementary to BPC-157's local angiogenic mechanism. In Clavicular's protocol context, TB-500 supports lean mass preservation and recovery during aggressive Retatrutide-driven fat loss. Molecular weight: 2174.5 Da.

Research Highlights

Satellite Cell Activation

TB-500 promotes satellite cell (muscle stem cell) entry into the cell cycle and differentiation into myoblasts. In vitro and animal models demonstrate increased satellite cell proliferation at injury sites, driving muscle regeneration. During aggressive caloric restriction with GLP-1 agonists, preserving lean mass is a key research priority.

Cardiac & Vascular Research

Multiple studies have examined Thymosin Beta-4 in cardiac repair post-infarction. Animal models demonstrate reduced cardiomyocyte apoptosis, improved neovascularization, and enhanced functional recovery. TB-500's VEGF upregulation and endothelial cell migration promotion are the primary vascular mechanisms.

Synergy with BPC-157

TB-500 and BPC-157 are the most studied peptide combination in healing research. BPC-157 drives local angiogenesis and growth factor upregulation; TB-500 drives systemic cell migration and actin regulation. The complementary pathways address both vascular and cellular aspects of repair.

Research FAQ

What is the difference between TB-500 and BPC-157?

TB-500 (Thymosin Beta-4 fragment) primarily acts via actin sequestration and satellite cell activation — most relevant to muscle and connective tissue repair. BPC-157 acts via VEGFR2, FAK-paxillin, and nitric oxide pathways with a broader tissue profile including GI cytoprotection. They are frequently studied in combination.

Why is TB-500 in Clavicular's recovery stack?

During aggressive caloric restriction protocols with Retatrutide, preserving lean mass is a research priority. TB-500's satellite cell activation and anti-catabolic properties in animal models provide a mechanistic rationale for its inclusion alongside BPC-157 in recovery-focused research stacks.

How should TB-500 be reconstituted?

Add 1–2mL bacteriostatic water to a 10mg vial. At 1mL: 10mg/mL. At 2mL: 5mg/mL. Store reconstituted at 4°C, use within 4 weeks.

Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.