Research Specifications
- Sequence:
- Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRADE-NH2)
- INCI Name:
- Acetyl Glutamyl Heptapeptide-3
- CAS Number:
- 868844-74-0
- Molecular Weight:
- 1075.2 Da
- Form:
- Lyophilized powder
- Purity:
- ≥98% (HPLC verified)
- Storage:
- −20°C long-term / 4°C up to 4 weeks
SNAP-8 10mg
Acetyl Octapeptide-3 — an 8-amino acid SNARE complex mimic studied for expression wrinkle reduction via neuromuscular junction modulation. The topical aesthetic component of the looksmaxxing stack.
SNARE Complex Inhibition at the Neuromuscular Junction
SNAP-8 (Acetyl Glutamyl Heptapeptide-3, CAS: 868844-74-0) is a synthetic octapeptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) that mimics the N-terminal end of SNAP-25, a key protein in the SNARE complex responsible for synaptic vesicle docking and neurotransmitter release. By competing with native SNAP-25 for SNARE complex formation, SNAP-8 modulates acetylcholine release at the neuromuscular junction — reducing contraction frequency and mechanical stress on the overlying dermis from repetitive facial expressions. Studies at 10% concentration in topical formulations have shown measurable reduction in forehead wrinkle depth after 4–28 days of twice-daily application. In looksmaxxing protocols, SNAP-8 addresses the neuromuscular component of facial aging — complementing GHK-Cu's structural collagen approach and Retatrutide's body composition effects. Molecular weight: 1075.2 Da.
Research Highlights
SNARE Complex Modulation
SNAP-8 targets the SNARE complex — the molecular machinery that drives synaptic vesicle fusion and neurotransmitter release. By competing with native SNAP-25 for complex assembly, it modulates acetylcholine release at the neuromuscular junction without blocking it entirely, preserving normal muscle function while reducing high-frequency contraction patterns.
Expression Line Research
The primary research application for SNAP-8 is expression wrinkle formation. Repetitive facial muscle contractions — squinting, frowning, smiling — create mechanical stress on the dermis that forms expression lines. SNAP-8 models investigate whether reducing contraction frequency via NMJ modulation can reduce this mechanical stress and formation rate.
Looksmaxxing Aesthetic Stack
In comprehensive looksmaxxing research protocols, SNAP-8 addresses the neuromuscular component of facial aging. Combined with GHK-Cu (collagen synthesis, skin matrix), BPC-157 (inflammation reduction), and systemic GLP-1 agonists for body recomposition, SNAP-8 contributes the surface-level wrinkle-depth mechanism.
Research FAQ
What is SNAP-8?
How does SNAP-8 fit in the looksmaxxing stack?
What concentration is used in SNAP-8 research?
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
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SNAP-8 10mg
$45.00